منابع مشابه
The Fibrinolytic Pathway of Human Plasma
The conversion of the plasminogen proactivator to plasminogen activator by activated Hageman factor or its fragments has been recognized as an essential step in the conversion of plasminogen to plasmin. The plasminogen proactivator has been completely separated from prekallikrein and pre-PTA, two other proenzyme substrates of activated Hageman factor or its fragments. Plasminogen proactivator, ...
متن کاملPlasma inhibitors of the components of the fibrinolytic pathway in man.
The effect of highly purified inhibitor of the first component of complement (CāINH), alpha2 macroglobulin (alpha2M), and alpha1 antitrypsin on the components of the fibrinolytic pathway in human plasma has been examined. CāINH was the only factor active upon the Hageman factor fragments functioning at the initial step of the fibrinolytic pathway, alpha2M was the only factor active against the ...
متن کاملEffect of chylomicrons on the fibrinolytic activity of normal human plasma in vitro.
The reported inhibition of fibrinolytic activity of blood plasma after ingestion of fat has been confirmed. It is shown that the ehylomicrons present in such plasma are responsible for this phenomenon. r r i H E PLASMA of normal fasted human _1_ subjects possesses fibrinolytic activity which can be quantitated by measuring the in vitro lysis of fibrin clots, plasma clots, or whole blood clots. ...
متن کاملAssay of procarboxypeptidase U, a novel determinant of the fibrinolytic cascade, in human plasma.
BACKGROUND Procarboxypeptidase U (proCPU) is a novel proenzyme found in human plasma. The active form, carboxypeptidase U (CPU; EC 3.4.17.20), retards the rate of fibrinolysis through its ability to cleave C-terminal lysine residues on fibrin partially degraded by plasmin. This reduces the number of high-affinity plasminogen-binding sites on fibrin. METHODS We developed an assay to determine ...
متن کاملHuman Plasma Extrinsic Pathway Inhibitor Activity : It . Plasma Levels in
Plasma or serum extrinsic pathway inhibitor (EPI) activity was measured in 24 patients with disseminated intravascular coagulation (DIC) and in 23 patients with severe hepatocellular disease. EPI was measured as activity in a test sample that inhibitied factor VIla/tissue factor (TF)catalyzed activation of 3H-factor IX (activation peptide release) in the presence of factor X. Of the 24 patients...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1972
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.136.6.1378